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Bioprospecting of novel marine terpenoids with broad commercial applications
Mission of the project
Mission of the project
Humanity relies upon innovation in nature to solve societal challenges, and always has. Anticancer and antiviral drugs are just some examples of the natural chemicals we have discovered that have saved countless lives.
Yet, just as nature is dominated by microorganisms we cannot grow in the lab, nature’s chemical diversity is also largely undiscovered. Advances in modern analytical tools and in computing are changing that situation.
In this project, we will use chemical and genomic tools to study the commercial potential and use of novel compounds called terpenoids, known to be the most diverse chemicals in nature.
Objective 1
Objective 1
Use a bio-guided fractionation workflow to test the bioactivity of marine crude extracts and fractions.
Objective 2
Objective 2
Use advanced nuclear magnetic resonance and mass spectrometry approaches to screen for marine terpenoids across selected organisms and niches.
Objective 3
Objective 3
Create metagenomic taxonomic and terpenoid biosynthetic gene cluster libraries to elucidate what organisms produce terpenoids.
Objective 4
Objective 4
Use cheminformatic tools to explore the diversity of detected compounds, target novel terpenoids, predict potential bioactivity and commercial potential.
Objective 5
Objective 5
Isolate and elucidate structures of high-potential target terpenoids.
Objective 6
Objective 6
Test upscaling potential to progress from Technology Readiness Levels (TRL)
Questions?
Questions?
Contact prospecter22[at]gmail.com or +353 1 220 5587 to get more information on the project
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